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Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

Interactions between the protein kinase C (PKC) and Chk1 inhibitor UCN-01 and the heat shock protein 90 (Hsp90) antagonist 17-AAG have been examined in human leukemia cells in relation to effects on signal transduction pathways and apoptosis. Simultaneous exposure (30 hours) of U937 monocytic leukemia cells to minimally toxic concentrations of 17-AAG (eg, 400 nM) and UCN-01 (eg, 75 nM) triggere...

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1967 Berkeley 1968 Berkeley 1969 Asilomar 1970 Tucson 1971 Asilomar 1972 Claremont 72:01–72:05 1973 Los Angeles 73:01–73:16 1974 Los Angeles 74:01–74:08 1975 Asilomar 75:01–75:23 1976 San Diego 1–65 i.e., 76:01–76:65 1977 Los Angeles 101–148 i.e., 77:01–77:48 1978 Santa Barbara 151–187 i.e., 78:01–78:37 1979 Asilomar 201–231 i.e., 79:01–79:31 1980 Tucson 251–268 i.e., 80:01–80:18 1981 Santa Bar...

ar X iv : h ep - p h / 01 01 17 6 v 1 1 6 Ja n 20 01 Determination of the Gaugino Mass Parameter M 1 in Different Linear Collider Modes 1

We study the different linear collider modes with regard to the determination of the gaugino mass parameterM1. In a specific mSUGRA inspired scenario we compare four processes with polarized beams: (a) ee → χ̃1χ̃2 → χ̃1χ̃1ee, (b) eγ → χ̃1ẽL/R → χ̃1χ̃1e, (c) γγ → χ̃1 χ̃−1 → χ̃1χ̃1eeνeν̄e, (d) ee → ẽ−L/Rẽ − L/R → χ̃1χ̃1ee.

Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort

We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, -B, and -C were typed to 4-digit resolution using sequence-based typing method. HLA class I haplotype frequencies were estimated using PyPop 32-0.6.0. The influence of haplotype...